21st.BIO - Cultivated X

21st.BIO Develops New Method for Scalable, Animal-Free Production of Essential Dairy Protein

July 10, 2025

21st.BIO has introduced a new development program focused on producing bovine alpha-lactalbumin (α-lac) using precision fermentation technology. The company, a leader in industrial-scale fermentation, has secured an exclusive license for a high-yield microbial strain developed by Novonesis, a biosolutions company. Unlocking the potential of α-Lac Alpha-lactalbumin is a milk protein recognized for its nutritional value. It is particularly rich in essential amino acids and is easy to digest, which makes …

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Fermentation

21st.BIO Engineers Safer Fungal Strain for Protein Production, Calls for EU Regulatory Reform

April 24, 2025

Biotech firm 21st.BIO has developed a new strain of Aspergillus oryzae, a filamentous fungus commonly used in fermentation, that has been engineered to remove all known pathways for producing mycotoxins — potentially harmful compounds sometimes found in fungi. The new strain, described in a peer-reviewed study published in Applied Microbiology and Biotechnology, was designed to avoid producing substances such as aflatoxins and other unwanted byproducts. It also eliminates the genes …

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Casein

Company News

21st.BIO’s Precision Fermented Whey for Animal-Free Dairy Obtains US GRAS Status

September 4, 2024September 4, 2024

Danish fermentation upscaling partner 21st.BIO announces that it has earned self-affirmed Generally Recognized as Safe (GRAS) status for its precision fermented beta-lactoglobulin, BLG Essential+. The GRAS milestone assures that 21st. BIO’s animal-free whey is safe for human consumption, allowing its commercialization within US territory. According to the biotech company, beta-lactoglobulin, the predominant protein in milk’s whey, has garnered significant interest from producers due to its high nutritional quality and beneficial properties …

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21st.BIO unveils a new pilot plant facility to accelerate the impact of biotech innovations globally.

Image courtesy of 21st.BIO

Fermentation

21st.BIO Unveils Cutting-Edge Facility to Accelerate Transition Between Lab and Large-Scale Fermentation

May 7, 2024

21st.BIO, a Danish bioproduction firm offering integrated end-to-end services, has launched a new pilot facility in its Danish headquarters in Søborg to facilitate and accelerate the transition between lab and large-scale fermentation of biotech innovations. At its new plant, 21st.BIO aims to guide and support early-stage startups or large companies in scaling the production of recombinant proteins and peptides with applications in nutrition, F&B, agriculture, biomaterials, and biopharma. The …

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scale up

Fermentation

21st.BIO Opens Access to its Large-Scale Production Platform for Animal-Free Dairy Proteins

February 7, 2024January 31, 2024

21st.BIO, a Danish bioproduction firm offering integrated end-to-end services, announces that it is granting access to its precision fermentation technology platform to produce animal-free dairy proteins. The new service aims to offer ingredient manufacturers, from startups to leading companies, cost-effective solutions to accelerate the development of sustainable dairy proteins at a competitive cost. 21st.BIO states it has the industry’s most advanced precision fermentation technology platform for large-scale production. Its fermentation technology …

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